Antibiotic-resistant “superbugs” remain a major public health threat, and only a multipronged attack can address the problem, a new U.S. government report warns.

The issue of antibiotic resistance isn’t new, and experts have long called for measures to combat it. Still, more than 2 million Americans fall ill each year from infections that are resistant to antibiotics, and roughly 23,000 die, according to the U.S. National Institute of Allergy and Infectious Diseases (NIAID).

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